Three seeded men left the draw on the same day. The 23rd seed Andrey Rublev lost to Daniel Merida Aguilar 6-7, 6-2, 6-4, 6-4; the 16th seed Brandon Nakashima lost to Alex Michelsen 6-3, 6-4, 6-4; and the 12th seed Rafael Jodar was beaten 6-2, 6-1, 6-1 by Bu Yunchaokete, who is in the draw as a lucky loser.
CBS Sports records Bu's win as the first time a lucky loser has beaten a top-15 seed at the US Open. The scoreline is the part that will be quoted: five games conceded by a seeded player to a man who had already lost in qualifying.
Rublev's exit is the one the draw notices most. His quarter opens up for the players seeded below him at exactly the point in the tournament where the second week starts to take shape.
Summarised by TennisArena from reporting by CBS Sports.